Supplement Facts:
 Other Ingredients: Microcrystalline Cellulose, Gelatin,
Magnesium Stearate, Silicon Dioxide, Water.
Suggested Use: As a
dietary supplement. Adults take one (1) capsule daily, preferably
with plenty of water, or as directed by a physician.
Caution: If you are pregnant, nursing or currently taking any
medication, consult with a physician prior to use. Do not exceed
suggested use.
Storage: Store this product in a cool dry place below 30°C
(86°F). Keep out of reach of children.
These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, cure or
prevent any disease(s).
Chromium (as Chromium Aspartate):
Chromium enhances the effect of insulin, and is believed to help reduce blood glucose levels. It is widely thought to be useful to people suffering from Type 2 (adult onset) diabetes by helping to avoid glycation (side effects of excess glucose), which damages proteins in the body. Chromium appears to work by being incorporated into glucose tolerance factor (GTF). GTF strengthens the action of insulin at the cellular level. The U.S. Department of Agriculture believes that most adults in the U.S. suffer from Chromium deficiency. Furthermore, levels of Chromium in the body appear to decline with age, suggesting a strong need for supplements. Chromium is often given in the form of Chromium Picolinate, but studies suggest that this form of Chromium can cause chromosome damage in high doses. Chromium Aspartate
is an alternative that has not been found to cause such side
effects.
Evening Primrose Oil Powder:
Evening Primrose Oil-Protects Nerves and Arteries;
Improves Blood Lipids. When Native American women first
chewed on evening primrose seeds to treat premenstrual
distress, little did they know that this herb would offer so
much to so many. The gamma-linolenic acid contained in
evening primrose oil is a popular treatment for multiple
ailments besides diabetic neuropathy, including PMS, acne,
joint pain, eczema, aging and infertility. It also reduces
nerve damage in type 1 and type 2 individuals and improves
blood lipid levels. Research supporting its diabetic
benefits comes from Japan and is found in the August 1993
and July 1991 issues of Prostaglandins Leukotrienes and
Essential Fatty Acids.
Alpha Lipoic Acid:
German favorite, Alpha-lipoic acid is used to treat
nerve damage caused by diabetes. The supplement demonstrated
its ability to reduce foot pain, burning and numbness caused
by diabetic neuropathy in the September 1997 issue of
Diabetes. The February 1999 issue of Diabetes Care reported
that Alpha-lipoic acid was found to reduce fasting blood
glucose concentrations in test subjects. Lipoic acid acts as
an antioxidant, helping to protect the cells of the liver
and brain. It may also prevent cataracts and improve the
effectiveness of other antioxidants, including vitamins E
and C.
Bitter Melon ( Momordica charantia ) (fruit):
Bitter Melon is named for its taste: it is eaten as
a vegetable in parts of Asia . Bitter melon has been
observed to lower blood sugar, possibly because of its
effect on beta cell function in the pancreas, where insulin
is produced. Research indicates that Bitter Melon is useful
in treating non-insulin dependent (Type 2) diabetes.
Research supporting chromium's benefits in diabetes is found
in several journals, including the October 1998 Nutrition
Review, 1998 Journal of Family Practice, and November 1997
issue of Diabetes.
Fenugreek ( Trigonella foenum-graecum ) (seed):
Fenugreek seeds' rich fiber slows the rate of
gastric emptying, inhibits the absorption of glucose in the
intestine, and lower cholesterol levels. Clinical studies
published in the European Journal of Clinical Nutrition
(April 1990 and January 1988) support the use of fenugreek
seeds to improve blood sugar control in both type 1 and type
2 diabetes. Products lacking either the whole seed or its
powder (fenugreek seed extracts and fenugreek tea) do not
provide this benefit.
Garcinia ( Garcinia cambogia ) (fruit):
Garcinia contains h ydroxycitric acid (HCA), which reduces the craving for sweets and enhances the effectiveness of the body's natural insulin. HCA allows muscles to absorb more glycogen. A "full" signal is then sent to the brain, resulting in reduced food intake and glycogen absorption. HCA also binds to excess glycogen in the bloodstream, which slows down the rate at which glycogen is converted to fat. HCA has been found to work best in combination with Chromium. Together, they increase the body's receptivity to insulin, which is crucial for people with Type 2 diabetes.
Gymnema (Standardized to contain 25% Gymnemic Acid) ( Gymnema sylvestre ) (leaf):
Gymnema Sylvestre Stimulates Insulin Release. Known
as the infamous "sugar destroyer" in India, gymnema
sylvestre was used for generations as an Indian folk remedy
for both type 1 and type 2 diabetes. Several studies,
including one published in the October 1990 Journal of
Enthno-pharmacology, support using gymnema sylvestre to
reduce blood glucose. Gymnema sylvestre stimulates the
release of the body's insulin, which may allow users to
reduce insulin or oral medication use. Such steps must not
be taken, however, without the supervision of a doctor or
other health care professional.
Vanadium (as Vanadium Amino Acid Chelate):
The human studies with vanadium executed so far are
impressive: they show that it can greatly reduce the needs
for insulin and hypoglycemic medications. Vanadium also
lowers blood sugar as well as the need for insulin. Vanadyl
sulfate has been found to benefit both Type I and Type II
diabetes. In humans it appears to have the insulin-mimicking
effect that Type I diabetics need, as well as the ability to
overcome the insulin resistance that is the defining
abnormality in Type II diabetes.
References:
Anon: National Research Council: Recommended Dietary Allowances , 10th ed. National Academy Press, Washington, DC, 1989:241-241.
Anderson , R.A., Polansky, M.M., Bryden, N.A. et al, Effects of supplemental chromium on patients with symptoms of reactive hypoglycemia . Metabolism . 1987: 36:351-355.
Beckles, G.L.A. et al, Diabetes Care . 1998;21:1432-1438.American Diabetes Association.
Biagi, P.L., Bordoni, A., Masi, M., Ricci, G., Fanelli, C., Patrizi, A., Ceccolini, E, A long-term study on the use of evening primrose oil (Efamol) in atopic children . Drug Exp Clin Res . 1988;14(4):285-90.
Cheng, H.H., Lai, M.H., Hou, W.C., Huang, C.L., Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects . J Agric Food Chem . 2004 Mar 10;52(5):1385-9
Cohen, N., Halberstam, M., Shlimovich, P., Chang, C.J., Shamoon, H. and Rossetti, L., Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus .
J Clin Invest
. 1995 June; 95(6): 2501–2509.
Dines, K.C., Cameron, N.E., Cotter, M.A,. Comparison of the effects of evening primrose oil and triglycerides containing gamma-linolenic acid on nerve conduction and blood flow in diabetic rats . J Pharmacol Exp Ther . 1995; 273(10:49-55.
Fang, C., Jiang, Z., Tomlinson, D.R., Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels . Prostaglandins Leukot Essent Fatty Acids . 1997; 56(2): 157-63.
Fushiki, T., Kojima, A., Imoto, T. et al. An extract of Gymnema sylvestre leaves and purified gymnemic acid inhibits glucose-stimulated gastric inhibitory peptide secretion in rats . J Nutr . 1992;122:2367–73. 1995.
Glinsmann, W.H. and Mertz, W., Effect of trivalent chromium on glucose tolerance . Metabolism . 1966;15:510-502.
Mada,r Z., Abel, R., Samish, S. and Arad , J., Glucose-lowering effect of fenugreek in non-insulin dependent diabetics . Eur J Clin Nutr 1988;42:51–4.
Raghuram, T.C., Sharma, R.D., Sivakumar, B. and Sahay, B.K., Effect of fenugreek seeds on intravenous glucose disposition in non-insulin dependent diabetic patients . Phytother Res 1994;8:83–6 .
Ribes, G., Sauvaire, Y., Da Costa, C. et al, Antidiabetic effects of subfractions from fenugreek seeds in diabetic dogs . Proc Soc Exp Biol Med 1986;182:159–66.
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